Miniaturized planar columns for use in a liquid phase separation apparatus

US6264892A · kind A · utility

Assignee

• AGILENT TECHNOLOGIES, INC. · US

Inventors

• Patrick Kaltenbach · Bischweier, DE
• Sally A. Swedberg · Santa Cruz, US
• Klaus Witt · Keltern, DE
• Fritz Bek · Remchingen, DE
• Laurie S. Mittelstadt · Belmont, US

Key dates

• Filing date: Jan 11, 2000
• Grant date: Jul 24, 2001
• Expiry date: Jan 11, 2020

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T156/1064
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Miniaturized planar column devices for use in a liquid phase separation apparatus are described. The devices include microstructures that have been fabricated by laser ablation in a variety of novel support substrates. Devices formed according to the methods of the invention include associated laser-ablated features required for function, such as on-device reservoirs or makeup flow compartments, analyte detection means and sample injection means. The miniaturized columns can be used in an apparatus intended for analysis of either small and/or macromolecular solutes in the liquid phase which employs chromatographic, electrophoretic or electrochromatographic separation means. The apparatus can include a variety of optional injection means, manifolds, keeper means, post column collection means, and combinations thereof.