Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
US6265399A · kind A · utility
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13Claims
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Key dates
| Filing date | Dec 8, 1999 |
| Grant date | Jul 24, 2001 |
| Priority date | — |
| Expiry date | Dec 8, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 ##STR1## The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.