Nucleic acid constructs whose activity is affected by inhibitors of cyclin-dependent kinases and uses thereof

US6265562A · kind A · utility

Assignee

• Aventis Pharma Deutschland GmbH · DE

Inventors

• Martin Eilers · Marburg, DE
• Andrea Buergin · Marburg, DE
• Hans-Harald Sedlacek · Marburg, DE

Key dates

• Filing date: Dec 18, 1998
• Grant date: Jul 24, 2001
• Expiry date: Dec 18, 2018

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application discloses nucleic acid constructs comprising nucleic acids which encode a protein which inhibits the cellular protein p27 and thereby relieves the inhibition of the proliferation of the cell which is brought about by p27, fragments and variants thereof, some of which possess a dominant interfering character.