Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
US6265716A · kind A · utility
96Cited by
28References
23Claims
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Key dates
| Filing date | Feb 29, 2000 |
| Grant date | Jul 24, 2001 |
| Priority date | — |
| Expiry date | Feb 29, 2020 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/22
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A sample preparation method is disclosed for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules. Photoabsorbing molecules having significant sublimation rates at room temperature under vacuum, and preferably containing hydroxy functionalities, are disclosed for use as matrices in matrix-assisted laser desorption/ionization mass spectrometry. The samples are typically cooled in the mass spectrometer to temperatures significantly below room temperature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.