Nuclear receptor ligands and ligand binding domains

US6266622A · kind A · utility

Assignee

• The Regents of the University of California · US

Inventors

• Thomas S. Scanlan · San Francisco, US
• John D. Baxter · West Melbourne, US
• Robert Fletterick · Hillsborough, US
• Richard L. Wagner · San Francisco, US
• Peter J. Kushner · San Francisco, US
• James Apriletti · Berkeley, US
• Brian West · San Francisco, US
• Andrew K. Shiau · San Francisco, US

Key dates

• Filing date: Nov 26, 1997
• Grant date: Jul 24, 2001
• Expiry date: Nov 26, 2017

Classification

• Technology area (CPC G): Physics
• CPC primary: G16B15/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides new methods, particularly computational methods, and compositions for the generation of nuclear receptor synthetic ligands based on the three dimensional structure of nuclear receptors, particularly the thyroid receptor (herein referred to as "TR"). Also provided are crystals, nuclear receptor synthetic ligands, and related methods.