Virus preparations and methods

US6267967A · kind A · utility

Assignee

• Cantab Pharmaceutical Research Limited · GB

Inventors

• Michael Johnston · Alpharetta, US
• Roderic Simon O'Keeffe · Witham, GB
• Nigel Kenneth Harry Slater · Maasdam, NL

Key dates

• Filing date: Mar 5, 1999
• Grant date: Jul 31, 2001
• Expiry date: Mar 5, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16651
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Herpesvirus preparations, e.g. cultured HSV type 2, e.g. genetically disabled virus for vaccine use, can be purified, e.g. for subsequent pharmaceutical formulation, with solid phase affinity reagents containing sulfate- or sulfonate-comprising binding groups, e.g. sulfated polysacharide groups, e.g. heparin or dextran sulfate, and eluting e.g. with salt solutions. The process can be combined with other culture and harvesting steps.