Process for the preparation of a controlled drug delivery system containing pseudoephedrine and a long acting antihistamine

US6267986A · kind A · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Girish Kumar Jain · Ashti, IN
• Ashok Rampal · Nakodar, IN
• Himadri Sen · Pune, IN

Key dates

• Filing date: Sep 24, 1999
• Grant date: Jul 31, 2001
• Expiry date: Sep 24, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/495
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to a process for the preparation of a controlled release pharmaceutical composition comprising two discrete zones wherein the first discrete zone comprises therapeutically effective amount of pseudoephedrine or its pharmaceutically acceptable salt as active ingredient and the second discrete zone comprises a therapeutically effective amount of a long-acting antihistamine selected from the group consisting of loratadine, azatidine, fexofenadine, terfenadine, cetirizine, astemizole, and levocabastine, or their pharmaceutically acceptable salt as active ingredient.