Polynucleotide encoding transcriptional intermediary factor-2
US6268173A · kind A · utility
2Cited by
1References
38Claims
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Key dates
| Filing date | Jul 11, 1997 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Jul 11, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/4702
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention concerns a nuclear receptor (NR) transcriptional mediator. More specifically, isolated nucleic acid molecules are provided encoding transcriptional intermediary factor-2 (TIF2). Recombinant methods for making TIF2 polypeptides are also provided as are TIF2 antibodies. Screening methods are also provided for identifying agonists and antagonists of the activation function AF-2 of nuclear receptors, for identifying agonists and antagonists of the AD1 activation domain activity of TIF2, and for identifying agonists and antagonists of the AD2 activation domain activity of TIF2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.