Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US6268199A · kind A · utility
54Cited by
1References
8Claims
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Key dates
| Filing date | Oct 12, 1999 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Oct 12, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/10034
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA virus, transfecting the host cell with the recombinant nucleic acid and selecting for infectious clones. The recombinant nucleic acid comprises at least one full-length DNA copy or in vitro-transcribed RNA copy or a derivative of either. The infectious clones can be used in single or dual purpose vaccines and in viral vector vaccines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.