Biotherapeutic virus attenuation using variable frequency microwave energy
US6268200A · kind A · utility
Assignees
Inventors
Key dates
| Filing date | Jan 15, 1999 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Jan 15, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2/12
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Virus attenuation is performed on a lyophilized biotherapeutic sealed within a microwave permeable container without harming the biotherapeutic and without exposing the biotherapeutic to additional viruses, by subjecting the container and biotherapeutic therewithin to variable frequency microwave energy. The container and biotherapeutic therewithin are swept with at least one range of microwave frequencies. Each range of microwave frequencies has a central frequency selected to break apart helix strands of a nucleic acid of the virus, to modify a capsid enclosing a nucleic acid of the virus, or to selectively couple to water molecules inside the capsid without harming the biotherapeutic or the container.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.