Formoterol process
US6268533A · kind A · utility
74Cited by
0References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 27, 2000 |
| Grant date | Jul 31, 2001 |
| Priority date | — |
| Expiry date | Jan 27, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method is disclosed for the preparation of optically pure isomers of formoterol by the reaction of an optically pure 4-benzyloxy-3-formamidostyrene oxide with an optically pure 4-methoxy-.alpha.-methyl-N-(phenylmethyl)benzeneethanamine followed by debenzylation. Useful intermediates in the process are also disclosed, as are the novel L-tartrate salt of R,R-formoterol and pharmaceutical compositions thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.