Nitric oxide-releasing metallic medical devices
US6270779A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 10, 2000 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | May 10, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/602
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. Furthermore, methods are provided for producing stable, silanized, sustained nitric oxide-releasing metallic medical devices.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.