Controlled-release garlic formulations
US6270803A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 7, 1998 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Oct 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5042
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There are provided orally-administrable formulations for the controlled release of granulated garlic, comprising particles of granulated garlic coated with a film comprising a mixture of at least one water soluble polymer and at least one water insoluble polymer, said at least one water soluble polymer and at least one water insoluble polymer being present in a ratio that produces a substantially zero order linear release pattern of at least one active ingredient. Preferably, the formulations are characterized in that the total in vitro dissolution time of said formulations required for release of 75% of the Allicin available from said formulations based upon the total amount of alliin initially present in said formulations is between about 4 and about 12 hours, as determined by U.S.P. XXIII paddle method at a paddle speed of 150 rpm, using simulated intestinal fluid without the digestive enzymes normally found in intestinal fluid, containing 0.1% w/w sodium dodecyl sulfate (SDS), at pH 6.8, and a temperature of 37.degree. C. A process for preparing the formulations of the invention is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.