Methods for high throughout determination and ranking of formulations and solubility
US6271038A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 15, 1999 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Dec 15, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/2575
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides apparatus and methods for formulation mixing and measurement to produce rank orders of solubility of chemicals in a variety of formulations. One such method includes mixing a volume of a stock solution having a known concentration of a chemical with a volume of a base liquid to form a control sample. Another volume of the stock solution is mixed with a volume of a formulation to form a test sample. The control sample is passed through a capillary electrochromatography (CEC) tube to separate the chemical from the base liquid, and the test sample is passed through a CEC tube to separate the chemical from the formulation. The method includes measuring the amount of chemical passing through the CEC tubes for both the control sample and the test sample, and comparing the measured amount of chemical from the control sample with the measured amount of chemical from the test sample to determine the solubility of the chemical in the formulation relative to the base liquid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.