Higher alkyl esters of cyanoacetic acid
US6271410A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jun 6, 2000 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Jun 6, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
C.sub.3-12 alkyl, substituted alkyl, alkenyl and cycloalkyl cyanoacetates are prepared by an efficient and simplified one-step process in which a small molar excess of the corresponding alcohol, i.e., C.sub.3-12 alkyl, substituted alkyl, alkenyl or cycloalkenyl alcohol is reacted with crystalline cyanoacetic acid, or a concentrated aqueous solution of cyanoacetic acid, in the presence of an acid catalyst, such as, for example, methanesulfonic acid, p-toluenesulfonic acid, sulfuric acid and phosphoric acid at a temperature in the range of from about 60.degree. C. to about 150.degree. C., in accordance with the following reaction: EQU CNCH.sub.2 COOH+R--OH.fwdarw..sup.(cat) CNCH.sub.2 COOR+H.sub.2 O (I) where R is a C.sub.3-12 alkyl, substituted alkyl, alkenyl or cycloalkyl.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.