Time-resolved, laser-induced fluorescence for the characterization of organic material
US6272376A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1999 |
| Grant date | Aug 7, 2001 |
| Priority date | — |
| Expiry date | Jan 22, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/6423
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of analysis of organic matter, called Time-Resolved, Laser-Induced Fluorescence Spectroscopy (TR-LIFS), characterizes and discriminates certain matter, such as tissue, by investigating the fluoresence response of the protein and lipid fluorophore components in both the spectral domain and time domain. This method is more robust than prior methods as (1) can investigate the matter at muplitple wavelengths and even across an entire spectrum and (2) is more sensitive to picking up weaker fluorescence signals such as that from lipids. A detailed study of the use of TR-LIFs for the charaterization of arterial wall tisse is described. A system and instrumentation for practicing the novel method is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.