Computer system and methods for producing morphogen analogs of human OP-1
US6273598A · kind A · utility
23Cited by
10References
21Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1997 |
| Grant date | Aug 14, 2001 |
| Priority date | — |
| Expiry date | Jan 22, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention disclosed herein provides methods and compositions for the computer-assisted design of morphogen analogs. Practice of the invention is enabled by the use of at least a portion of the atomic co-ordinates defining the three-dimensional structure of human osteogenic protein-1 (hOP-1) as a starting point in the design of the morphogen analogs. In addition, the invention provides methods for producing morphogen analogs of interest, and methods for testing whether the resulting analogs mimic or agonize human OP-1-like biological activity. The invention also provides a family of morphogen analogs produced by such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.