Method for rapid cooling and warming of biological materials
US6274303A · kind A · utility
58Cited by
5References
21Claims
0Family size
Inventors
Key dates
| Filing date | May 10, 1999 |
| Grant date | Aug 14, 2001 |
| Priority date | — |
| Expiry date | May 10, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/162
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
A method of cooling and rewarming large organs and tissues at sub-zero temperatures is provided. The method includes perfusion of tissue with inert fluids that remain liquid at very low temperatures. The inert fluids can include fluorocarbons, silicones, or fluorosilicones. Glycol ethers are used as a novel class of cryoprotective agents for organ and tissue preservation. The glycol ethers have improved viscosity, penetration, and glass forming properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.