Pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds
US6274572A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 21, 1998 |
| Grant date | Aug 14, 2001 |
| Priority date | — |
| Expiry date | Dec 21, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J31/006
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The subject of the invention is the products of formula (I): ##STR1## in which either R.sub.1 represents halogen, hydroxyl, (C.sub.1 -C.sub.8) alkyloxy or (C.sub.1 -C.sub.12) acyloxy, and R.sub.2 represents halogen or hydrogen, or R.sub.1 and R.sub.2 form together a double bond, Z is chosen from optionally substituted (C.sub.1 -C.sub.8) alkylthio, optionally substituted arylthio, (C.sub.1 -C.sub.8) alkyloxy, halogen, cyano, mercapto, thiocyanato and (CH.sub.2).sub.0-1 --CO.sub.2 H, optionally esterified, Y represents hydrogen or methyl, the dotted line in position 1-2 or 5-6 optionally representing a second bond, as well as their addition salts, their preparation process, the intermediates of this process and the pharmaceutical compositions containing them.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.