Dihydropyrimidines and uses thereof

US6274585A · kind A · utility

Assignee

• Synaptic Pharmaceutical Corporation · US

Inventors

• Donghui Cui · Newtown, US
• Margaret R. Davis · Redmond, US
• Michael Dunn · Cambridge, US
• Ben E. Evans · Lansdale, US
• Hanumath P. Kari · Hatfield, US
• Bharat Lagu · Maywood, US
• Dhanapalan Nagarathnam · Bethany, US
• Kamlesh P. Vyas · Harleysville, US
• Kanyin Zhang · San Diego, US

Key dates

• Filing date: Dec 23, 1999
• Grant date: Aug 14, 2001
• Expiry date: Dec 23, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention is directed to dihydropyrimidines which are selective antagonists for human .alpha..sub.1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the .alpha..sub.1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.