Fenofibrate pharmaceutical composition having high bioavailability and method for preparing it
US6277405A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 18, 2000 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | May 18, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2081
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a micronized fenofibrate composition. The micronized fenofibrate composition has a dissolution of at least 10% in 5 minutes, 20% in 10 minutes, 50% in 20 minutes and 75% in 30 minutes, as measured using the rotating blade method at 75 rpm according to the European Pharmacopoeia, in a dissolution medium constituted by water with 2% by weight polysorbate 80 or with 0.025M sodium lauryl sulfate. The composition can further comprise hydrophilic polymers, surfactants, hydrosoluble carriers, outer phases or layers, or other pharmaceutically acceptable excipients. The immediate-release fenofibrate composition is preferably in the form of a tablet or in the form of granules inside a capsule.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.