Method for identifying a hedgehog-mediated phosphorylation state dependent transcription factor
US6277566A · kind A · utility
4Cited by
2References
5Claims
0Family size
Inventors
Key dates
| Filing date | Feb 13, 1998 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | Feb 13, 2018 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides transcription factors associated with the hedgehog signaling pathway that are regulated by dephosphorylation by phosphatases. Hedgehog response elements (HRE) that interact with the dephosphorylated transcription factors are also provided as well as methods for identifying compounds that are phosphatase inhibitors. Methods of treating tumors in a subject by modulating the phosphorylation of the transcription factor are also included.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.