Affinity labeling libraries and applications thereof
US6277583A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Feb 7, 1996 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | Feb 7, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC40B70/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Novel methods and compositions are provided for preferentially bonding an oligomeric molecule to a macromolecular target where the target is a member of a complex mixture and/or there is preferential bonding at one of a plurality of available bonding sites of the macromolecular target. The methods represent a complete system for both producing and identifying affinity label molecules from a combinatorial library which preferentially bind to a marcomolecular target or target site and preferentially binding those affinity labels to a macromolecule of interest either ex vivo or in vivo. Macromolecular targets include a variety of cellular- and non-cellular-associated proteins.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.