Pharmaceutical formulations of nerve growth factor
US6277828A · kind A · utility
18Cited by
2References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 20, 1993 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | Aug 20, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/839
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stable, aqueous pharmaceutical formulations of human nerve growth factor (NGF) in aqueous isotonic solutions, buffered to maintain the pH from about 4.5 to about 6.0, and optionally containing a carrier such as human serum albumin are provided. Also provided are aqueous NGF formulations suitable for lyophilization and subsequent reconstitution in which rhNGF is admixed with sugars, optionally HSA, and buffer. The formulations are useful for the treatment of Alzheimer's disease and other neuronal disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.