5'-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon

US6277830A · kind A · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Ashit K. Ganguly · Upper Montclair, US
• Jinping McCormick · Edison, US
• Raymond G. Lovey · West Caldwell, US
• Frank Bennett · Piscataway, US
• Anil K. Saksena · Upper Montclair, US
• Viyyoor M. Girijavallabhan · Parsippany, US

Key dates

• Filing date: Jul 7, 1999
• Grant date: Aug 21, 2001
• Expiry date: Jul 7, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

5'-Amino acid esters of ribavirin represented by formula I: ##STR1## wherein R is CH.sub.3 CH(NH.sub.2)--CO--, CH.sub.3 CH.sub.2 (CH.sub.3)CHCH(NH.sub.2)--CO--or H.sub.2 N(CH.sub.2).sub.4 CH(NH.sub.2)--CO--; preferably R is ##STR2## or a pharmaceutically acceptable salt thereof, e.g., trifluoroacetate, tosylate, mesylate, and chloride, pharmaceutical compositions containing them as well as methods of treating patients having susceptible viral infections, e.g., chronic hepatitis C infections by administering a therapeutically effective amount of a ribavirin derivative, alone or in combination with a therapeutically effective amount of interferon-alpha are disclosed.