Piperazinyl 5-HT1 agonists and antagonists
US6277852A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Apr 14, 1999 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | Apr 14, 2019 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D333/38
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of the formula ##STR1## or the pharmaceutically acceptable salt thereof, wherein PA1 Z is oxygen, S(O).sub.m wherein m is 0, 1 or 2; or NQ wherein Q is hydrogen, (C.sub.1 -C.sub.6)alkyl or phenyl; PA1 X is hydrogen, chloro, fluoro, bromo, iodo, hydroxy, nitro, cyano, (C.sub.1 -C.sub.6)alkyl, trifluoromethyl, (C.sub.1 -C.sub.6)alkoxy, (C.sub.1 -C.sub.6)alkyl S(O).sub.a wherein a is 0, 1 or 2; or phenyl wherein the phenyl group is optionally substituted; PA1 Y is ##STR2## wherein M is oxygen or sulfur; PA1 X.sup.2 is hydrogen, fluoro, chloro, trifluoromethyl, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy or (C.sub.1 -C.sub.6)alkyl S(O).sub.c wherein c is 0, 1 or 2; PA1 R.sup.1 is selected from ##STR3## PA1 wherein R.sup.6 is selected from the group consisting of hydrogen, optionally substituted (C.sub.1 -C.sub.6)alkyl; and wherein R.sup.6 in G.sup.5 together with R.sup.7 form a 2 carbon chain; and R.sup.9 and R.sup.10 are independently hydrogen or (C.sub.1 -C.sub.6)alkyl; PA1 R.sup.2 is hydrogen, (C.sub.1 -C.sub.4)alkyl, phenyl or naphthyl, wherein said phenyl or naphthyl may optionally substituted; and PA1 R.sup.3 is --(CH.sub.2).sub.t B, wherein t is 0-3 and B is hyd…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.