Anti-convulsant isoquinolyl-benzamide derivatives

US6277861A · kind A · utility

Assignee

• SmithKline Beeacham P.L.C. · GB

Inventors

• John David Harling · Harlow, GB
• Barry Sidney Orlek · Harlow, GB
• Mervyn Thompson · Harlow, GB

Key dates

• Filing date: Dec 21, 1999
• Grant date: Aug 21, 2001
• Expiry date: Dec 21, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) and pharmaceutically acceptable salts thereof, where R.sup.1 is hydrogen, C.sub.1-6 alkyl (optionally substituted by hydroxy or C.sub.1-4 alkoxy), C.sub.1-6 alkenyl, C.sub.1-6 alkynyl, C.sub.1-6 alkylCO--, formyl, CF.sub.3 CO-- or C.sub.1-6 alkylSO.sub.2 --; R.sup.2 is hydrogen or up to three substituents selected from halogen, NO.sub.2, CN, N.sub.3, CF.sub.3 O--, CF.sub.3 S--, CF.sub.3 CO--, trifluoromethyldiazirinyl, C 1-6?alkyl, C.sub.1-6 alkenyl, C.sub.1-6 alkynyl, C.sub.1-6 perfluoroalkyl, C.sub.3-6 cycloalkyl, C.sub.3-6 cycloalkyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylO--, C.sub.1-6 alkylCO--, C.sub.3-6 cycloalkylO--, C.sub.3-6 cycloalkylCO--, C.sub.3-6 cycloalkyl-C.sub.1-4 alkylO--, C.sub.3-6 cycloalkyl-C.sub.1-4 alkylCO--, phenyl, phenoxy, benzyloxy, benzoyl, phenyl-C.sub.1-4 alkyl-, C.sub.1-6 alkylS--, C.sub.1-6 alkylSO.sub.2 --, (C.sub.1-4 alkyl).sub.2 NSO.sub.2 --, (C.sub.1-4 alkyl)NHSO.sub.2 --, (C.sub.1-4 alkyl).sub.2 NCO--, (C.sub.1-4 alkyl)NHCO-- or CONH.sub.2 ; or --NR.sup.5 R.sup.6 where R.sup.5 is hydrogen or C.sub.1-4 alkyl, and R.sup.6 is hydrogen, C.sub.1-4 alkyl, formyl, --CO.sub.2 C.sub.1-4 alkyl or --COC.sub.1-4 alkyl; or two R.sup.2 grou…