Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors

US6277877A · kind A · utility

Assignee

• PFIZER INC. · US

Inventors

• Dennis J. Hoover · Stonington, US
• Bernard Hulin · Essex, US
• William H. Martin · Holmdel, US
• Douglas Phillips · Millerton, US
• Judith Treadway · Gales Ferry, US

Key dates

• Filing date: Aug 15, 2000
• Grant date: Aug 21, 2001
• Expiry date: Aug 15, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula (I) ##STR1## wherein PA1 R.sub.6 is carboxy, (C.sub.1 -C.sub.8)alkoxycarbonyl, benzyloxycarbonyl, C(O)NR.sub.8 R.sub.9 or C(O)R.sub.12 as glycogen phosphorylase inhibitors, pharmaceutical compositions containing such inhibitors and the use of such inhibitors to treat diabetes, hyperglycemia, hypercholesterolemia, hypertension, hyperisulinemia, hyperlipidemia, atherosclerosis and myocardial ischemia in mammals.