Substituted indole compounds as anti-inflammatory and analgesic agents
US6277878A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 26, 1999 |
| Grant date | Aug 21, 2001 |
| Priority date | — |
| Expiry date | Aug 26, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a compound of the following formula: ##STR1## or the pharmaceutically acceptable salts thereof wherein R.sup.1 is H or C.sub.1-4 alkyl; R.sup.2 is C(.dbd.L')R.sup.3 or So.sub.2 R.sup.4 ; Y is a direct bond or C.sub.1-4 alkylene; L and L' are independently oxygen or sulfur; Q is selected from the following: C.sub.1-6 alkyl, halo-substituted C.sub.1-4 alkyl, optionally substituted C.sub.3-7 cycloalkyl, optionally substituted phenyl or naphthyl, optionally substituted 5 or 6-membered monocyclic aromatic group; R.sup.3 is --OR.sup.6, --NR.sup.7 R.sup.8, N(OR.sup.1)R.sup.7 or a group of formula: ##STR2## Z is a direct bond, O, S or NR.sup.5 ; R.sup.4 is C.sub.1-6 alkyl, halo-substituted C.sub.1-4 alkyl, optionally substituted phenyl or naphthyl; R.sup.5 is C.sub.1-4 alkyl or halo-substituted C.sub.1-4 alkyl; R.sup.6 is C.sub.1-4 alkyl C.sub.3-7 cycloalkyl, C.sub.1-4 alkyl-C.sub.3-7 cycloalkyl, halo-substituted C.sub.1-4 alkyl, optionally substituted C.sub.1-4 alkyl-phenyl or phenyl; R.sup.7 and R.sup.8 are each selected from the following: H, optionally substituted C.sub.1-6 alkyl, optionally substituted C.sub.3-7 cycloalkyl, optionally substituted C.sub.1-4 alky…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.