Sulfonylamino acid and sulfonylamino hydroxamic acid derivatives

US6277987A · kind A · utility

Assignee

• Novartis AG · CH

Inventors

• Paivi Jaana Kukkola · Whitehouse Station, US
• Leslie Robinson · Del Mar, US
• Motowo Nakajima · Ashiya, JP
• Junichi Sakaki · Kawasaki, JP

Key dates

• Filing date: Feb 3, 1999
• Grant date: Aug 21, 2001
• Expiry date: Feb 3, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula ##STR1## wherein PA1 W is --OH or --NHOH; PA1 X is a heterocycle with the proviso that when X is a nitrogen containing heterocycle, the heterocycle is attached to the (CH.sub.2).sub.m moiety by a ring nitrogen, --CONR.sub.2 R.sub.3, --NR.sub.1 COR.sub.2, --NR.sub.1 SO.sub.2 R.sub.2, --NR.sub.1 CONR.sub.2 R.sub.3, --NR.sub.1 COOR.sub.4, heteroarylthio, alkylthio, arylalkylthio, heteroarylalkylthio, heterocycloalkylalkylthio, heterocycloalkylthio or arylthio; PA1 Y is carbon, nitrogen, oxygen or sulfur, provided that when Y is carbon, n is 2; PA1 Z is alkyl, aryl, alkoxy, aryloxy, aralkoxyaryl, aralkoxyheteroaryl, heteroaryl, heterocycloalkyl, heteroaryloxy, --CONR.sub.2 R.sub.3, --NR.sub.1 COR.sub.2, --NR.sub.1 CONR.sub.2 R.sub.3, --OCONR.sub.2 R.sub.3, --NR.sub.1 COOR.sub.4, or --SO.sub.2 R.sub.2 ; PA1 R.sub.1 is hydrogen, alkyl, heterocycloalkylalkyl, aralkyl or heteroarylalkyl; PA1 R.sub.2 and R.sub.3 are independently R.sub.1, aryl or heteroaryl; or R.sub.2 and R.sub.3 taken together with the nitrogen atom to which they are attached form a 5- to 7-membered ring, which may optionally contain another heteroatom selected from oxygen, nitrogen and sulfur; PA1 R.…