Solvent-free method for preparing sterically hindered phosphoramidates

US6277988A · kind A · utility

Assignee

• General Electric Company · US

Inventors

• John R. Campbell · Clifton Park, US
• James Anthony Cella · Clifton Park, US
• Gregory Ronald Gillette · Clifton Park, US
• John E. Kochanowski · Stockbridge, US
• Matthew Ladd Reitz · Clifton Park, US

Key dates

• Filing date: Feb 29, 2000
• Grant date: Aug 21, 2001
• Expiry date: Feb 29, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6521
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Sterically hindered phosphoramidates such as N,N'-bis[di-(2,6-xylenoxy)phosphinyl]piperazine are prepared by the reaction of a sterically hindered diaryl chlorophosphate, such as di-(2,6-xylyl) chlorophosphate, with a basic nitrogen compound containing at least two basic N--H groups, preferably a heterocyclic compound such as piperazine, in a predominantly liquid, solvent-free reaction mixture. The reaction may be conducted in the melt or in the presence of a non-solvent carrier, typically an aliphatic hydrocarbon. An excess of the basic nitrogen compound is employed as an acid acceptor.