Quinazoline derivatives as medicaments

US6277989A · kind A · utility

Assignee

• SCIOS INC. · US

Inventors

• Sarvajit Chakravarty · Sunnyvale, US
• Sundeep Dugar · Bound Brook, US
• John Perumattam · Los Altos, US
• George Schreiner · Los Altos Hills, US
• David Liu · Palo Alto, US
• John A. Lewicki · Los Gatos, US

Key dates

• Filing date: Mar 14, 2000
• Grant date: Aug 21, 2001
• Expiry date: Mar 14, 2020

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention is directed to methods to inhibit TGF-.beta. and/or p38-.alpha. kinase using compounds of the formula ##STR1## or the pharmaceutically acceptable salts thereof PA1 wherein R.sup.3 is a noninterfering substituent; PA1 each Z is CR.sup.2 or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N; PA1 each R.sup.2 is independently a noninterfering substituent; PA1 L is a linker; PA1 n is 0 or 1; and PA1 Ar' is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.