Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo[4.3. 0]nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives

US6278013A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Stefan Bartel · Bensberg, DE
• Thomas Jaetsch · Cologne, DE
• Thomas Himmler · Odenthal, DE
• Hans-Georg Rast · Odenthal, DE
• Werner Hallenbach · Nordhorn, DE
• Ernst Heinen
• Franz Pirro · Langenfeld, DE
• Martin Scheer · Wuppertal, DE
• Michael Stegemann · Lenexa, US
• Hans-Peter Stupp · Leverkusen, DE
• Heinz-Georg Wetzstein · Leverkusen, DE

Key dates

• Filing date: Nov 21, 2000
• Grant date: Aug 21, 2001
• Expiry date: Nov 21, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P33/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Intermediates useful in the preparation of 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo[4.3. 0]nonan-8-yl-6-fluorol,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the following structures are claimed. ##STR1##