Peptide-coated implants and methods for producing same

US6280760A · kind A · utility

Assignee

• MERCK PATENT GESELLSCHAFT MIT BESHRANK TER HAFTUNG · DE

Inventors

• Jorg Meyer · Egelsbach, DE
• Alfred Jonczyk · Darmstadt, DE
• Berthold Nies · Kassel, DE
• Horst Kessler · Schwalbach, DE
• Dirk Finsinger · Darmstadt, DE
• Martin Kantlehner · Freising, DE

Key dates

• Filing date: Nov 22, 1999
• Grant date: Aug 28, 2001
• Expiry date: Nov 22, 2019

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/50
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.