Use of a non-mammalian DNA virus to express an exogenous gene in a mammalian cell
US6281009A · kind A · utility
23Cited by
6References
75Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Sep 11, 1997 |
| Grant date | Aug 28, 2001 |
| Priority date | — |
| Expiry date | Sep 11, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/85
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are methods, nucleic acids, and cells for expressing an exogenous gene in a mammalian cell, involving introducing into the cell a non-mammalian DNA virus (e.g., a baculovirus) whose genome carries an exogenous gene, and growing the cell under conditions such that the gene is expressed. Also disclosed are methods for treating gene deficiency disorders, neurological disorders, or cancers in a mammal by providing to a cell a therapeutically effective amount of a virus whose genome carries an exogenous, therapeutic gene and growing the cell under conditions such that the exogenous gene is expressed in the mammal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.