Functional characterization of the C-C chemokine-like molecules encoded by molluscum contagiosum virus types 1 and 2
US6281200A · kind A · utility
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Key dates
| Filing date | Aug 13, 1998 |
| Grant date | Aug 28, 2001 |
| Priority date | — |
| Expiry date | Aug 13, 2018 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The inventors have cloned and expressed the chemokine-like genes from MCV type 1 and the closely related MCV type 2 in order to determine a potential role for these proteins in the viral life cycle. These are the first viral chemokines that have been shown to antagonize the chemotactic activity of human chemokines and the first viral chemokines that have been shown to have inhibitory activity on human hematopoietic progenitor cells. Methods and compositions for exploiting these proteins are disclosed herein.
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