Macrocyclic compounds as metalloprotease inhibitors
US6281352A · kind A · utility
6Cited by
1References
50Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 1997 |
| Grant date | Aug 28, 2001 |
| Priority date | — |
| Expiry date | May 14, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tissue degradation and inhibitors of the release of tumor necrosis factor. The present invention also relates to pharmaceutical compositions comprising such compounds and to methods of using these compounds for the treatment of inflammatory diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.