Immunogenic compositions comprising soluble, non-cleavable, chimeric HIV-1 gp160-variants
US6284248A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Jun 7, 1995 |
| Grant date | Sep 4, 2001 |
| Priority date | — |
| Expiry date | Jun 7, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/16122
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Immunogenic compositions comprising soluble, non-cleavable, chimeric HIV-1 gp160 variants capable of eliciting human immunodeficiency virus type 1 (HIV-1) gp160-specific antibodies are provided. These HIV-1 gp160 variants comprise the following regions: i) a first region derived from the gp160 of a first strain of HIV-1; ii) a second region derived from the gp160 of a second strain of HIV-1 wherein said second region fails to contain functional major and minor proteolytic cleavage sites (amino acids 483-486 and 475-479, respectively) and functional major and minor hydrophobic domains (amino acids 487-516 and 659-680, respectively); and iii) an optional third region, derived from the gp160 of said second strain, located at the amino terminus of the recombinant envelope.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.