Pharmaceutical compositions of meloxicam with improved solubility and bioavailability

US6284269A · kind A · utility

Assignee

• Hexal AG · DE

Inventors

• Andreas Struengmann · Holzkirchen, DE
• Brigitte Freudensprung · Holzkirchen, DE
• Karin Klokkers · Holzkirchen, DE

Key dates

• Filing date: May 10, 2000
• Grant date: Sep 4, 2001
• Expiry date: May 10, 2020

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions containing enolic carboxamide type antiinflammatory agent meloxicam that exhibit improved wettability, aqueous solubility, dissolution behaviour over a broad range of pH, and that are prepared by crystal structure modification of the drug through dry or wet mechanical homogenization with two further components--one of them is selected from a group of oligo--and dissolution improving, or alkalizing agent. The application of the formulations according to the present invention results in an improved biovailability and effectiveness of meloxicam.