Methods of using plasma expanders and blood substitutes
US6284452A · kind A · utility
4Cited by
18References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 6, 1999 |
| Grant date | Sep 4, 2001 |
| Priority date | — |
| Expiry date | Jul 6, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A blood substitute solution and methods for its use are provided. The subject solution contains: subphysiological amounts of potassium ion, 0-10 mM magnesium ion, 70-160 mM sodium ion, 0.5-4.0 mM calcium ion, and 80-170 mM chloride ion; one or more water soluble oncotic agents; an organic carboxylic acid or salt thereof; physiological amounts of a sugar; and a blood clotting factor. The subject solution is further characterized in that it does not include a conventional biological buffer. The subject solutions find use in a variety of different applications, e.g. as blood volume expanders, and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.