Polynucleotides encoding fatty acid transport proteins
US6284487A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 14, 1999 |
| Grant date | Sep 4, 2001 |
| Priority date | — |
| Expiry date | Jan 14, 2019 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/044
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among the organs of mammals. Nucleic acids encoding FATPs of this family, are described. Also described are methods to test FATPs for fatty acid transport function, and methods to identify inhibitors or enhancers of transport function. The altering of LCFA uptake by administering to the mammal an inhibitor or enhancer of FATP transport function of a FATP can decrease or increase calories available as fats, and can decrease or increase circulating fatty acids. The organ specificity of FATP distribution can be exploited in methods to direct drugs, diagnostic indicators and so forth to an organ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.