Nonpeptide kappa opioid receptor antagonists

US6284769A · kind A · utility

Assignee

• The Board of Trustees of the University of Illinois · US

Inventors

• William A. Dunn · Beltsville, US
• Ludwig Bauer · Stuttgart, DE
• Hemendra N. Bhargava · Wheaton, US

Key dates

• Filing date: Dec 3, 1999
• Grant date: Sep 4, 2001
• Expiry date: Dec 3, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compounds of structural formulae (I) and (II) ##STR1## and use of the compounds and salts and hydrates thereof, as therapeutic agents, is disclosed. A compound of formula (I) or (II) is an agonist for the .mu. and .delta. opioid receptors, an antagonist for the .kappa. opioid receptor, and has high affinity at all three receptors. A compound of formula (I) or (II) has utility in a variety of therapeutic and research areas where .kappa. opioid receptor antagonism is beneficial, including the treatment of opiate addiction or pain, or in a method of stimulating an immune system of a human.