Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6284794A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 4, 1999 |
| Grant date | Sep 4, 2001 |
| Priority date | — |
| Expiry date | May 4, 2019 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tension-type headache is treated by interacting with neuronal transmission in relation to pain in connection with headache in a way which prevents or decreases sensitization of second order nociceptive neurons. In particular, treatment is performed by administration of an effective amount of a substance which prevents or decreases central sensitization. Important examples of such substances are substances which interact with nitric oxide, such as nitric oxide synthase (NOS) inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA. According to a broader aspect of the invention tension-type headache is treated by administration of substances which are effective in preventing or decreasing pain in connection with tension-type headache, such as the substances mentioned above. Accordingly, the invention relates to treatment of tension-type headache by administration of substances which substantially inhibit the activity of nitric oxide synthase (NOS), such as NOS inhibitors, such as L-NMMA or L-NAME or L-NIO or L-NNA.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.