Patent · US Expired

Chicken embryo lethal orphan (CELO) virus GAM-1

US6284880A · kind A · utility

1Cited by

3References

2Claims

0Family size

Assignee

Boehringer Ingelheim International GmbH · DE

Inventors

Matthew Cotten · Wien, AT
Adam Baker · Wien, AT
Susanna Chiocca · Wien, AT

Key dates

Filing date	Feb 14, 1997
Grant date	Sep 4, 2001
Priority date	—
Expiry date	Feb 14, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2710/10322
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The toxicity problems which occur when foreign material is introduced into higher eukaryotic cells, particularly during transfection with DNA, are countered by causing gene products to be expressed in the cell, which block the apoptosis triggered by the transfection process, and/or by treating the cells with anti-inflammatory substances. Preferably, Bcl-2, E1B 19K or an anti-apoptotically active gene of chicken adenovirus CELO is used as the anti-apoptosis gene whilst the inflammatory substance used is adenovirus VA1, which is introduced into the cell in the form of VA1-DNA. Using these methods, long-lasting gene expression can be achieved.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.