Dinitrile intermediates for the synthesis of omapatrilat and methods for producing same
US6284901A · kind A · utility
2Cited by
4References
20Claims
0Family size
Assignee
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Key dates
| Filing date | Jun 7, 2000 |
| Grant date | Sep 4, 2001 |
| Priority date | — |
| Expiry date | Jun 7, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D317/30
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using the S-stereoisomer of a racemic mixture. The racemic mixture may be prepared from a hydantoin (III). The hydantoin may be prepared from a novel dinitrile compound (IV): ##STR1## The dinitrile may be produced by reacting a monoacetal with a non-carbonate ammonium salt and an alkali cyanide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.