Pharmaceutical compositions of vanadium biguanide complexes and their use

US6287586A · kind A · utility

Assignee

• University of British Columbia · CA

Inventors

• Chris Orvig · Vancouver, CA
• John H. McNeill · Vancouver, CA

Key dates

• Filing date: Sep 15, 1999
• Grant date: Sep 11, 2001
• Expiry date: Sep 15, 2019

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions of vanadium biguanide complexes, and methods of use, are provided for the treatment of hyperglycemia and related disorders, e.g. hypertension, obesity, and lipid disturbances. The pharmaceutically active complexes of the invention comprise a biguanide chelant, preferably a 1-substituted biguanide chelant, capable of chelating vanadium to form a six-membered unsaturated vanadium-containing ring. The vanadium of the complex is coordinated with oxygen, sulphur or nitrogen, particularly oxygen coordinated. The complexes are formulated with a physiologically acceptable carrier. In a preferred embodiment, the complexes are formulated for oral administration.