Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof
US6287588A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 27, 2000 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Apr 27, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.