Irreversible cysteine protease inhibitors containing vinyl groups conjugated to electron withdrawing groups
US6287840A · kind A · utility
25Cited by
6References
32Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 18, 1999 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Aug 18, 2019 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Irreversible cysteine protease inhibitors based upon an alkene bond being conjugated to an electron withdrawing group are disclosed. The inhibitor structure also provides a targeting peptide which is specific for different cysteine proteases. The method of making the inhibitors, and methods of using the inhibitors to inhibit cysteine proteases and for therapy are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.