Compositions and methods for controlling genetically engineered organisms
US6287844A · kind A · utility
8Cited by
2References
5Claims
0Family size
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Inventors
Key dates
| Filing date | Feb 6, 1998 |
| Grant date | Sep 11, 2001 |
| Priority date | — |
| Expiry date | Feb 6, 2018 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/74
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Compositions and methods for the control of genetically engineered organisms are described. A more effective cell suicide approach is contemplated based on the conditional expression of the lethal Streptomyces avidinii streptavidin gene. Toxicity of streptavidin is derived from its exceptionally high binding affinity for an essential prosthetic group, D-biotin. The general requirement for biotin through the living world makes streptavidin-based conditional lethal designs applicable to a broad range of containment strategies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.