Patent · US Expired

Evolution of whole cells and organisms by recursive sequence recombination

US6287862A · kind A · utility

210Cited by

37References

48Claims

0Family size

Assignee

Maxygen, Inc. · US

Inventors

Stephen delCardayre · Belmont, US
Matthew Tobin · San Jose, US
Willem P. C. Stemmer · Los Gatos, US
Jon E. Ness · Sunnyvale, US
Jeremy Minshull · Los Altos, US
Phillip A. Patten · Portola Valley, US
Venkiteswaran Subramanian · Coralville, US
Linda A. Castle · Mountain View, US
Claus M. Krebber · Mountain View, US
Steven H. Bass · Hillsborough, US

Key dates

Filing date	Jul 26, 2000
Grant date	Sep 11, 2001
Priority date	—
Expiry date	Jul 26, 2020

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12R2001/465
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.